Mindfulness, stress and the brain

When people hear the word “mindfulness,” many imagine a Buddhist monk sitting for hours under a tree meditating. Others might think it’s some esoteric practice, accessible only to those involved in spiritual teachings. The truth is, mindfulness is a simple and effective method for improving mental health.

What is mindfulness?

Mindfulness meditation is a practice in psychology borrowed from Buddhist traditions. In the Western world, mindfulness refers to the ability to pay conscious attention by observing what is happening in the present moment — without judgment. This definition also highlights the core aspects of mindfulness practice:

  • Observing – The way we perceive our inner world and the environment around us.
  • Describing – The ability to describe what we are experiencing in words.
  • Awareness в действията си – What we choose to do after we have paid attention to the situation in the present moment.
  • Non-judging – This is perhaps the most challenging part of mindfulness. Our mind constantly evaluates whether what we think and experience is good or bad, right or wrong, fair or unfair, important or trivial… Non-judgment in mindfulness practice means being aware of these automatic evaluations, acknowledging them, to accept them as they are and not adding another “layer” of judgment on top. 
  • Non-reactivity – Allowing thoughts and feelings to exist — without being consumed by them and without letting them control our actions.

Is there a single “right” way to practice? 

Most of you have probably heard of meditation with breathing, body scanning, focusing on an object, observing and accepting your thoughts, and many more techniques. But mindfulness can also be practiced in everyday life. We can be aware, observe without judgment, and stay present in the moment in any situation throughout our day — while talking to someone, walking, eating, or brushing our teeth. 

The more we practice formally, the easier it becomes to stay mindful in everyday life. Conversely, the more aware we are in daily activities, the easier it is to engage in mindfulness meditation. 

The good news is that both formal and informal practice lead to an increase in our psychological flexibility and stress resilience.

The connection between mindfulness and mental health.

Mindfulness practice and various therapies based on mindfulness (ACT, MBSR, MBCT) have a significant impact on improving mental health. Numerous studies show that these approaches help people manage stress, anxiety and depression symptoms, and other psychological conditions. They have even been found effective in reducing chronic pain and blood pressure.

Why is this the case? Mindfulness helps us become more aware of what is happening in the present moment and notice our patterns of thought. This allows us to take a step back and observe things from a distance: to recognize early signs of stress, anxiety, and depression, and respond to them appropriately. 

The more aware we are of what’s happening within us and around us, the easier it becomes to adapt to the challenges we face.

What is stress?

Stress can be defined as a threat to the body — a threat that may be real or imagined. Regardless of whether the danger is actual or not, it triggers a stress response in the body and brain — mobilizing both body and mind to cope with the challenge.

While moderate levels of stress are adaptive and beneficial, chronic and intense stress is associated with a range of mental and physical health issues, including depression, anxiety, post-traumatic stress disorder, memory problems, and immune system dysfunction. This is because stress activates the hypothalamic-pituitary-adrenal (HPA) axis, leading to the release of cortisol and other hormones in the body. These hormones help allocate energy appropriately and respond to threats. However, chronic cortisol release can be harmful to both physical and mental health.

That’s why it’s important to actively manage and reduce chronic and intense stress in our daily lives. Stress reduction plays a crucial role in the treatment of people with psychiatric and medical conditions. One effective way to achieve this is through practicing mindfulness.

How does mindfulness reduce stress?

Regular mindfulness practices enhance wellbeing in various ways:

  • Повишават осъзнатостта за реакцията ни на стрес;
  • Развиват умението да се дистанцираме и да приемаме мислите и чувствата без да ги осъждаме;
  • Подпомагат способността за нереактивност към стреса – да възприемаме мислите и чувствата без да реагираме на тях и без те да контролират действията ни; 
  • Регулират освобождаването на кортизол – важен биомаркер за реакцията към стрес;
  • Оптимизират работата на хипоталамо-хипофизно-надбъбречната ос (HPA axis), която регулира стрес отговора в тялото.

In the following lines, you’ll learn about some of the brain mechanisms through which mindfulness affects stress.

Hippocampus, stress and mindfulness.

The hippocampus is part of the brain’s limbic system, involved in managing emotions and memory, and also plays a role in regulating the HPA axis, which is key to the stress response. There is a reciprocal relationship between cortisol levels and the structural and functional integrity of the hippocampus. This means that excessive cortisol can damage the hippocampus. Hippocampal atrophy is linked to various psychopathologies and is thought to result from the stress response, which is characteristic of many mental health issues. Mindfulness has the potential to protect the hippocampus by reducing the stress response. 

What changes occur in the brain when we meditate regularly?

Numerous studies show that regular mindfulness practice is associated with structural changes in the brain. The most evidence exists for changes in gray matter volume in the hippocampus. These findings come from MRI studies of long-term meditators.

Researchers suggest that the increase in gray matter in the subiculum (a part of the hippocampus that suppresses stress anticipation and integrates information) may form the neural basis that allows meditators to consciously choose among different responses during stressful situations. This, in turn, leads to more appropriate reactions to both minor daily stressors and major life events. This ability is what we refer to as non-reactivity  – a core aspect of mindfulness.

What can you do to increase your self-awareness?

Self-awareness is a key skill that helps us understand and manage ourselves, as well as respond appropriately to our surroundings. It forms the foundation for personal growth, effective communication, and resilience to stress. Here are a few practical tips:

Build a habit of practicing mindfulness.

Choose a specific time or daily activity to focus on the present moment. This could be during your morning coffee, while taking a walk, or even while washing the dishes. Start with short intervals — 5–10 minutes a day — and gradually increase the duration.

Pause and check.

In moments of stress or tension, pause for a moment and ask yourself: “What am I feeling right now? What is worrying me?”

Mindful breathing.

Focus on your breathing. Notice how the air flows in and out of your body without trying to change it.

Cultivate curiosity and acceptance.

Try observing your thoughts and feelings without judging them. Instead of criticizing yourself for negative thoughts or difficult emotions, approach them with curiosity: “What are these thoughts telling me? How can they be useful to me?”

You are not alone!

If you’re feeling overwhelmed or believe you can’t manage on your own, we at Growth Space are here to support you. We offer scientifically proven techniques for coping with stress and emotional strain, as well as individual consultations. 

Sign up for our webinar: "How to use neuroscience to achieve our goals?"and take the first step to a calmer, more aware and focused life!

Start your journey toward a better version of yourself!